THE EFFECT OF PCV-13 (Pneumococcus Conjugation Vaccine-13) IMMUNIZATION ON THE INCIDENCE OF ARI IN TODDLERS IN URBAN AND RURAL AREAS OF BANDUNG DISTRICT
DOI:
https://doi.org/10.37160/mijournal.v21i02.833Keywords:
ARI Incidence, PCV-13 Immunization, Urban and rural areasAbstract
Background: Acute Respiratory Tract Infection (ARI) is an acute infectious disease that affects one or more parts of the respiratory tract, from the nose to the alveoli, including the adnexal tissue such as the sinuses, middle ear cavity, and pleura. According to the WHO, pneumonia contributed to 14% of deaths in toddlers in the world in 2019. The WHO recommends that all countries use the Pneumococcal Conjugate Vaccine (PCV) in routine infant immunization. Objective: This study aims to analyze the effect of Pneumococcus Conjugation Vaccine-13 (PCV-13) Immunization on the incidence of ARI in toddlers in urban and rural areas of Bandung Regency. Method: The study employed a cohort study design. The sample in this study consisted of toddlers aged 1-3 years who were registered at the health center posyandu, with both urban and rural characteristics in Bandung Regency, totaling 240 samples. The dependent variable is the incidence of ARI in toddlers. In contrast, the independent variables are the administration of Pneumococcus Conjugation Vaccine-13 (PCV-13) immunization, gender, age of toddlers, nutritional status, immunization history, parental occupation, maternal knowledge, and maternal education. Univariate data analysis to determine the frequency distribution of variables, bivariate analysis using the Chi-Square test, and multivariate analysis using logistic regression. Results of the study: The results showed a significant relationship between the administration of Pneumococcus Conjugation Vaccine-13 (PCV-13) immunization and the incidence of ARI with a p-value of 0.0001 <0.05 and an RR value of 0.000 <1 in urban areas and a p-value in rural areas is 0.0001 <0.05 with an RR value of 0.167 <1 meaning that the administration of Pneumococcus Conjugation Vaccine-13 (PCV-13) immunization can reduce the incidence of ARI in toddlers in both urban and rural areas. Conclusion: Toddlers who receive complete doses of Pneumococcus Conjugation Vaccine-13 (PCV-13) immunization will be protected from ARI
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References
Abha, P., & Deepti, P. (2018). Risk factors of acute lower respiratory tract infection: a study in hospitalized central Indian children under 5 years of age. MOJ Current Research & Reviews, 1(3), 129–133. https://doi.org/10.15406/mojcrr.2018.01.00020
Ahmed, K. Y., Page, A., Arora, A., Ogbo, F. A., Agho, K. E., Diallo, T., Ezeh, O. E., Uchechukwu, O. L., Ghimire, P. R., Akombi, B. J., Ogeleka, P., Abir, T., Issaka, A. I., Rwabilimbo, A. G., Subramanee, D., Nagdev, N., & Dhami, M. (2020). Associations between infant and young child feeding practices and acute respiratory infection and diarrhoea in Ethiopia: A propensity score matching approach. PLoS ONE, 15(4), 1–20. https://doi.org/10.1371/journal.pone.0230978
Alemayehu, S., Kidanu, K., Kahsay, T., & Kassa, M. (2019). Risk factors of acute respiratory infections among under five children attending public hospitals in southern Tigray, Ethiopia, 2016/2017. BMC Pediatrics, 19(1), 1–8. https://doi.org/10.1186/s12887-019-1767-1
Anteneh, Z. A., & Hassen, H. Y. (2020). Determinants of acute respiratory infection among children in ethiopia: A multilevel analysis from ethiopian demographic and health survey. International Journal of General Medicine, 13, 17–26. https://doi.org/10.2147/IJGM.S233782
Cacho, N. T., & Lawrence, R. M. (2017). Innate immunity and breast milk. Frontiers in Immunology, 8(MAY). https://doi.org/10.3389/fimmu.2017.00584
Centers for Disease Control. (2022). Penyakit Pneumokokus Penyakit dan Vaksinasi Pneumokokus Global Penyakit pneumokokus global. https://www.cdc.gov/pneumococcal/global.html
Chan, J., Gidding, H. F., Blyth, C. C., Fathima, P., Jayasinghe, S., McIntyre, P. B., Moore, H. C., Mulholland, K., Nguyen, C. D., Andrews, R., & Russell, F. M. (2021). Levels of pneumococcal conjugate vaccine coverage and indirect protection against invasive pneumococcal disease and pneumonia hospitalisations in Australia: An observational study. PLoS Medicine, 18(8), 1–21. https://doi.org/10.1371/journal.pmed.1003733
Cinta, A. (2018). Hubungan Tingkat Pendidikan Ibu Dengan Kejadian Infeksi Saluran Pernapasan Atas Pada Balita. Citra Delima : Jurnal Ilmiah STIKES Citra Delima Bangka Belitung, 2(1), 17–22. https://doi.org/10.33862/citradelima.v2i1.7
Control, C. for D. (2006). Pneumococcal conjugate vaccine. What you need to know. South Dakota Medicine : The Journal of the South Dakota State Medical Association, 59(12), 528–529.
Cox, M., Rose, L., Kalua, K., de Wildt, G., Bailey, R., & Hart, J. (2017). The prevalence and risk factors for acute respiratory infections in children aged 0-59 months in rural Malawi: A cross-sectional study. Influenza and Other Respiratory Viruses, 11(6), 489–496. https://doi.org/10.1111/irv.12481
Dagne, H., Andualem, Z., Dagnew, B., & Taddese, A. A. (2020). Acute respiratory infection and its associated factors among children under-five years attending pediatrics ward at University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia: Institution-based cross-sectional study. BMC Pediatrics, 20(1), 1–7. https://doi.org/10.1186/s12887-020-1997-2
Damanik, P., Siregar, M. A., & Aritonang, E. Y. (2018). Correlation between Nutritional Status, Exclusive Breastfeeding, Basic Immunization Status, and the Incidence of Acute Respiratory Infection (ARI) in Children Aged 12-24 Months in the Work Area of the Glugur Darat Health Center, Medan City. Nutrition, Reproductive Health and Epidemiology, 1(4), 1–7.
DINKES Kabupaten Bandung. (2022). Profile Kesehatan Kabupaten Bandung Tahun 2022.
Direktorat Pengelolaan Imunisasi Kementerian Kesehatan RI. (2022). Petunjuk Teknis Pelaksanaan Penumokokus Konyugasi (PCV).
Dirjen P2PM Kemenkes RI. (2022). Laporan Kinerja Laporan Kinerja Laporan Kinerja.
Fathmawati, F., Rauf, S., & Indraswari, B. W. (2021). Factors related with the incidence of acute respiratory infections in toddlers in Sleman, Yogyakarta, Indonesia: Evidence from the Sleman Health and Demographic Surveillance System. PLoS ONE, 16(9 September), 1–13. https://doi.org/10.1371/journal.pone.0257881
Fitranti, D. Y., Wijayanti, H. S., Tsani, A. F. A., & Panunggal, B. (2023). Panduan Praktikum Penilaian Status Gizi. In UIN Walisongo Semarang.
Hemilä, H. (2017). Vitamin C and infections. Nutrients, 9(4). https://doi.org/10.3390/nu9040339
J.W. Senterfitt, A. Long, M. Shih, S. M. T. (2013). How Social and Economic Factors Affect Health. Social Determinants of Health. Los Angels County Department of Public Health, 1(January), 1–24.
Kemenkes RI. (2017a). Panduan Tatalaksana Pneumonia Balita.
Kemenkes RI. (2017b). Pedoman dan Standar Etik Penelitian dan Pengembangan Kesehatan Nasional. Kementerian Kesehatan RI, 1–158. http://www.depkes.go.id/article/view/17070700004/program-indonesia-sehat-dengan-pendekatan-keluarga.html
Kemenkes RI. (2018). Hasil Riset Kesehatan Dasar Tahun 2018. Kementrian Kesehatan RI, 53(9), 1689–1699.
Kemenkes RI. (2020). Permenkes RI No 2 Tahun 2020. Kementerian Kesehatan RI, 167(1), 1–5. https://www.e-ir.info/2018/01/14/securitisation-theory-an-introduction/
Kementerian Kesehatan. (2019). Pedoman Pencegahan Pengendalian ISPA. 2019.
Nurwahidah, N., & Haris, A. (2019). Pengetahuan Orangtua Berhubungan Dengan Kejadian ISPA Pada Balita Di Puskesmas Kumbe Kota Bima. Jurnal Keperawatan Terpadu (Integrated Nursing Journal), 1(2), 9. https://doi.org/10.32807/jkt.v1i2.32
Paulus, A. Y., Sulaeman, Mayasari, A. C., Ayu, J. D., Musniati, N., Sari, M. P., Hamdan, D. F., Farid, A., Selly, J. B., Amalia, N., Aulia, U., & Adnyana, I. M. D. M. (2023). Biostatistika Epidemiologi (Issue 1).
Prasiwi, N. W., Ristanti, I. K., FD, T. Y., & Salamah, K. (2021). Hubungan Antara Status Gizi dengan Kejadian ISPA pada Balita. Cerdika: Jurnal Ilmiah Indonesia, 1(5), 560–566.
Prayitno, A., Supriyatno, B., Munasir, Z., Karuniawati, A., Hadinegoro, S. R. S., Prihartono, J., Safari, D., Sundoro, J., & Khoeri, M. M. (2021). Pneumococcal nasopharyngeal carriage in Indonesia infants and toddlers post-PCV13 vaccination in a 2+1 schedule: A prospective cohort study. PLoS ONE, 16(1 January), 1–14. https://doi.org/10.1371/journal.pone.0245789
Purnama, S. G. (2016). Buku Ajar Penyakit Berbasis Lingkungan. Ministry of Health of the Republic of Indonesia, 112.
Ridwan, S. F., Rohima, W., Sudarsono, W., Septina, S. A., & Putri, S. R. (2021). Faktor Risiko Fisiologis Penyebab Kejadian Infeksi Saluran Pernafasan Akut (ISPA) pada Balita: Literatur Riview. JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan), 6(1), 85–95.
Riyanto, A. (2022). Pengolahan dan analisis data Data Kesehatan. Nuha Medika.
Saputri, E., Endarti, D., & Andayani, T. M. (2020). Tingkat Pengetahuan Orang Tua terhadap Penyakit Pneumonia dan Imunisasi Pneumococcal Conjugate Vaccine (PCV) di Indonesia. JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice), 10(2), 156. https://doi.org/10.22146/jmpf.54423
Sultana, M., Sarker, A. R., Sheikh, N., Akram, R., Ali, N., Mahumud, R. A., & Alam, N. H. (2019). Prevalence, determinants and health care-seeking behavior of childhood acute respiratory tract infections in Bangladesh. PLoS ONE, 14(1), 1–18. https://doi.org/10.1371/journal.pone.0210433
Sutriana, V. N., Sitaresmi, M. N., & Wahab, A. (2021). Risk factors for childhood pneumonia: a case-control study in a high prevalence area in Indonesia. Clinical and Experimental Pediatrics, 64(11), 588–595. https://doi.org/10.3345/CEP.2020.00339
Taksande, A. M., & Yeole, M. (2016). Risk factors of Acute Respiratory Infection (ARI) in under-fives in a rural hospital of Central India. Journal of Pediatric and Neonatal Individualized Medicine, 5(1). https://doi.org/10.7363/050105
Tian, J., Zheng, B., Yang, L., Guan, Y., Xu, C., & Wang, W. (2023). Effectiveness of 13-valent pneumococcal conjugate vaccine on all-cause pneumonia in children under 5 years in Shanghai, China: An observational study. Vaccine, 41(41), 5979–5986. https://doi.org/10.1016/j.vaccine.2023.08.041
Troeger, C., Blacker, B., Khalil, I. A., Rao, P. C., Cao, J., Zimsen, S. R. M., Albertson, S. B., Deshpande, A., Farag, T., Abebe, Z., Adetifa, I. M. O., Adhikari, T. B., Akibu, M., Al Lami, F. H., Al-Eyadhy, A., Alvis-Guzman, N., Amare, A. T., Amoako, Y. A., Antonio, C. A. T., … Reiner, R. C. (2018). Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory infections in 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet Infectious Diseases, 18(11), 1191–1210. https://doi.org/10.1016/S1473-3099(18)30310-4
Tromp, I., Jong, J. K. De, Raat, H., Jaddoe, V., Franco, O., Hofman, A., De Jongste, J., & Moll, H. (2017). Breastfeeding and the risk of respiratory tract infections after infancy: The Generation R Study. PLoS ONE, 12(2), 1–12. https://doi.org/10.1371/journal.pone.0172763
UNICEF. (2022). Responding to COVID-19. https://doi.org/10.4018/978-1-6684-3504-5.ch011
Weaver, R., Nguyen, C. D., Chan, J., Vilivong, K., Lai, J. Y. R., Lim, R., Satzke, C., Vongsakid, M., Newton, P. N., Mulholland, K., Gray, A., Dubot-Pérès, A., Dance, D. A. B., & Russell, F. M. (2020). The effectiveness of the 13-valent pneumococcal conjugate vaccine against hypoxic pneumonia in children in Lao People’s Democratic Republic: An observational hospital-based test-negative study. The Lancet Regional Health - Western Pacific, 2, 100014. https://doi.org/10.1016/j.lanwpc.2020.100014
WHO & UNICEF. (2006). Pneumonia: the forgotten killer of children.
WHO & UNICEF. (2015). Ending preventable child deaths from pneumonia and diarrhoea by 2025. Development of the integrated Global Action Plan for the Prevention and Control of Pneumonia and Diarrhoea. Archives of Disease in Childhood, 100, S23–S28. https://doi.org/10.1136/archdischild-2013-305429
World Health Organization. (2014). Revised WHO Classification and Treatment of Childhood Pneumonia at Health Facilities: Evidence Summaries. In Who.
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