Hubungan Antara Berbagai Komorbiditas Dengan Derajat Keparahan Pasien Covid-19 Di Rumah Sakit Siloam Kebon Jeruk Jakarta
DOI:
https://doi.org/10.37160/mijournal.v20i2.465Keywords:
komorbiditas, penyakit yang sudah ada sebelumnya, derajat keparahan, faktor risiko, epidemiologi, COVID-19Abstract
Derajat keparahan COVID-19 pada setiap pasien sangat bervariasi, dari kasus ringan, berat, kritis, hingga kematian. Dikatakan bahwa komorbiditas berperan dalam progresivitas serta kematian pada pasien COVID-19. Berdasarkan Satuan Tugas Penanganan COVID-19 (SATGAS COVID-19) di Indonesia, hipertensi, diabetes melitus, penyakit paru obstruktif kronis, penyakit ginjal, kanker, gangguan imun dan asma berada di 12 besar komorbiditas yang sering ditemukan pada pasien COVID-19. Prevelansi orang dengan komorbiditas di Indonesia tidak sedikit, maka dari itu penting untuk diteliti dan dikonfirmasi lebih lanjut hubungan komorbiditas dengan derajat keparahan pada pasien COVID-19, karena identifikasi faktor risiko akan menolong tenaga kesehatan mengidentifikasi pasien dengan faktor risiko tinggi untuk mendapatkan perawatan lebih intensif. Menggunakan studi analitik cross-sectional, didapatkan data penelitian melalui total population sampling rekam medis dari 135 pasien. Data yang dikumpulkan meliputi komorbiditas serta derajat keparahan pasien COVID-19 berdasarkan kriteria World Health Organization. Hasil penelitian menunjukan bahwa mayoritas pasien COVID-19 tergolong pada derajat keparahan sedang tanpa oksigen (34,1%) diikuti dengan derajat sedang dengan oksigen (30,4%), ringan (21,5%), dan berat (14,1 %). Selain itu didapatkan bahwa, komorbiditas terbanyak adalah diabetes melitus (30,4%). Dengan menggunakan uji chi-square didapatkan hubungan yang bermakna antara diabetes melitus dan derajat keparahan pasien COVID-19 (P = 0,000). Terdapat juga hubungan yang bermakna antara multi-komorbiditas dengan derajat keparahan pasien COVID-19 (P=0,000). Oleh karena tingginya prevelansi komorbiditas terutama diabetes melitus dan juga multi-komorbiditas, penelitian ini diharapkan dapat memaparkan pentingnya identifikasi serta kontrol komorbiditas pada masyarakat untuk dapat mencapai penurunan tingkat kematian dan derajat berat pada pasien COVID-19.
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References
Abate, S. M., Ali, S. A., Mantfardo, B., & Basu, B. (2020). Rate of Intensive Care Unit admission and outcomes among patients with coronavirus: A systematic review and Meta-analysis. PLOS ONE, 15(7), e0235653. https://doi.org/10.1371/JOURNAL.PONE.0235653
Al-Sabah, S., Al-Haddad, M., Al-Youha, S., Jamal, M., & Almazeedi, S. (2020). COVID-19: Impact of obesity and diabetes on disease severity. Clinical Obesity, 10(6). https://doi.org/10.1111/cob.12414
Aveyard, P., Gao, M., Lindson, N., Hartmann-Boyce, J., Watkinson, P., Young, D., Coupland, C. A. C., Tan, P. S., Clift, A. K., Harrison, D., Gould, D. W., Pavord, I. D., & Hippisley-Cox, J. (2021). Association between pre-existing respiratory disease and its treatment, and severe COVID-19: a population cohort study. The Lancet Respiratory Medicine, 9(8), 909–923. https://doi.org/10.1016/S2213-2600(21)00095-3
Chen, K., Lei, Y., He, Y., Xiao, F., Yu, Y., Lai, X., Liu, Y., Wang, J., & Dai, H. (2021). Clinical outcomes of hospitalized COVID-19 patients with renal injury: a multi-hospital observational study from Wuhan. Scientific Reports 2021 11:1, 11(1), 1–12. https://doi.org/10.1038/s41598-021-94570-1
Chhiba, K. D., Patel, G. B., Vu, T. H. T., Chen, M. M., Guo, A., Kudlaty, E., Mai, Q., Yeh, C., Muhammad, L. N., Harris, K. E., Bochner, B. S., Grammer, L. C., Greenberger, P. A., Kalhan, R., Kuang, F. L., Saltoun, C. A., Schleimer, R. P., Stevens, W. W., & Peters, A. T. (2020). Prevalence and characterization of asthma in hospitalized and nonhospitalized patients with COVID-19. Journal of Allergy and Clinical Immunology, 146(2), 307-314.e4. https://doi.org/10.1016/J.JACI.2020.06.010
Clark, A., Jit, M., Warren-Gash, C., Guthrie, B., Wang, H. H. X., Mercer, S. W., Sanderson, C., McKee, M., Troeger, C., Ong, K. L., Checchi, F., Perel, P., Joseph, S., Gibbs, H. P., Banerjee, A., Eggo, R. M., Nightingale, E. S., O’Reilly, K., Jombart, T., … Jarvis, C. I. (2020). Global, regional, and national estimates of the population at increased risk of severe COVID-19 due to underlying health conditions in 2020: a modelling study. The Lancet Global Health, 8(8), e1003–e1017. https://doi.org/10.1016/S2214-109X(20)30264-3
Filardo, T. D., Khan, M. R., Krawczyk, N., Galitzer, H., Karmen-Tuohy, S., Coffee, M., Schaye, V. E., Eckhardt, B. J., & Cohen, G. M. (2020). Comorbidity and clinical factors associated with COVID-19 critical illness and mortality at a large public hospital in New York City in the early phase of the pandemic (March-April 2020). PLOS ONE, 15(11), e0242760. https://doi.org/10.1371/JOURNAL.PONE.0242760
Haleem, A., Javaid, M., & Vaishya, R. (2020). Effects of COVID-19 pandemic in daily life. Current Medicine Research and Practice, 10(2), 78. https://doi.org/10.1016/J.CMRP.2020.03.011
Honardoost, M., Janani, L., Aghili, R., Emami, Z., & Khamseh, M. E. (2021). The Association between Presence of Comorbidities and COVID-19 Severity: A Systematic Review and Meta-Analysis. Cerebrovascular Diseases, 50(2), 132–140. https://doi.org/10.1159/000513288
Huang, B. Z., Chen, Z., Sidell, M. A., Eckel, S. P., Martinez, M. P., Lurmann, F., Thomas, D. C., Gilliland, F. D., & Xiang, A. H. (2021). Asthma Disease Status, COPD, and COVID-19 Severity in a Large Multiethnic Population. Journal of Allergy and Clinical Immunology: In Practice, 9(10), 3621-3628.e2. https://doi.org/10.1016/j.jaip.2021.07.030
Jain, V., & Yuan, J. M. (2020). Predictive symptoms and comorbidities for severe COVID-19 and intensive care unit admission: a systematic review and meta-analysis. International Journal of Public Health, 65(5), 533–546. https://doi.org/10.1007/s00038-020-01390-7
Kim, S. R., Nam, S. H., & Kim, Y. R. (2020). Risk Factors on the Progression to Clinical Outcomes of COVID-19 Patients in South Korea: Using National Data. International Journal of Environmental Research and Public Health 2020, Vol. 17, Page 8847, 17(23), 8847. https://doi.org/10.3390/IJERPH17238847
Petrilli, C. M., Jones, S. A., Yang, J., Rajagopalan, H., O’Donnell, L., Chernyak, Y., Tobin, K. A., Cerfolio, R. J., Francois, F., & Horwitz, L. I. (2020). Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study. BMJ, 369. https://doi.org/10.1136/BMJ.M1966
Price-Haywood, E. G., Burton, J., Fort, D., & Seoane, L. (2020). Hospitalization and Mortality among Black Patients and White Patients with Covid-19. New England Journal of Medicine, 382(26), 2534–2543. https://doi.org/10.1056/NEJMSA2011686/SUPPL_FILE/NEJMSA2011686_DISCLOSURES.PDF
Turan, O., Arpınar Yigitbas, B., Turan, P. A., & Mirici, A. (2021). Clinical characteristics and outcomes of hospitalized COVID-19 patients with COPD. Expert Review of Respiratory Medicine, 15(8), 1069–1076. https://doi.org/10.1080/17476348.2021.1923484
Xiong, S., Liu, L., Lin, F., Shi, J., Han, L., Liu, H., He, L., Jiang, Q., Wang, Z., Fu, W., Li, Z., Lu, Q., Chen, Z., & Ding, S. (2020). Clinical characteristics of 116 hospitalized patients with COVID-19 in Wuhan, China: a single-centered, retrospective, observational study. BMC Infectious Diseases, 20(1), 1–11. https://doi.org/10.1186/S12879-020-05452-2/FIGURES/2
Zhang, L., Zhu, F., Xie, L., Wang, C., Wang, J., Chen, R., Jia, P., Guan, H. Q., Peng, L., Chen, Y., Peng, P., Zhang, P., Chu, Q., Shen, Q., Wang, Y., Xu, S. Y., Zhao, J. P., & Zhou, M. (2020). Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China. Annals of Oncology, 31(7), 894–901. https://doi.org/10.1016/J.ANNONC.2020.03.296
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